evidence card · statin_myalgia_largely_nocebo
Most statin-associated muscle symptoms are nocebo/expectancy and resolve under blinded conditions
H4
▲ supports
stakes critical
6 posts scored
·
across 1 account
·
2 sources
Summary
SAMSON and ASCOT-LLA blinded phases show muscle symptoms reported similarly on placebo and statin. Approximately 90% of patients reporting intolerance tolerate re-challenge.
Five-score assessment
Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)
Scope
Population
adults on statins reporting myalgia
Intervention
blinded or re-challenge trials
Outcome
muscle-symptom incidence vs placebo
Not supported for
- claim that statin myopathy as a distinct entity doesn't exist (rare but real)