evidence card · metformin_human_lifespan
Metformin extends lifespan in humans without diabetes
H3
? insufficient
stakes moderate
1 post scored
·
across 1 account
·
3 sources
Summary
UKPDS showed CV benefit in T2DM. Observational studies in non-diabetics are confounded. TAME trial was proposed but has not read out. May even blunt exercise mitochondrial gains.
Five-score assessment
Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)
Scope
Population
adults without diabetes
Intervention
metformin
Outcome
lifespan, all-cause mortality
Not supported for
- routine use for longevity in non-diabetics