evidence card · metformin_blunts_exercise_gains
Metformin blunts mitochondrial adaptations to exercise
H3
▲ supports
stakes moderate
1 post scored
·
across 1 account
·
2 sources
Summary
MASTERS trial and mechanistic studies suggest blunting of some adaptations. Relevant for longevity-seeking non-diabetics combining metformin with exercise.
Five-score assessment
Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)
Scope
Population
older adults starting exercise
Intervention
metformin during training
Outcome
VO2max, muscle mitochondrial markers
Not supported for
- claim metformin fully abolishes exercise benefit in all populations