evidence card · ldl_paradox_elderly_reverse_causation
Higher LDL in older adults is cardioprotective
H1
▽ contradicts
stakes critical
2 posts scored
·
across 2 accounts
·
2 sources
Summary
The apparent 'LDL paradox' in elderly cohorts is largely confounded by illness-related cholesterol decline (reverse causation). Mendelian randomization and statin RCTs in older adults (including STAREE and prior CTT analyses) show LDL lowering continues to benefit.
Five-score assessment
Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)
Scope
Population
older adults
Intervention
higher LDL as protective
Outcome
CV events, mortality
Not supported for
- any claim higher LDL protects against CVD in elderly