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evidence card · ldl_causal_cvd

LDL cholesterol is causal for atherosclerotic cardiovascular disease

H5 ▲ supports stakes critical
25 posts scored · across 8 accounts · 3 sources

Summary

Mendelian randomization, RCTs of LDL-lowering (statins, PCSK9i, ezetimibe), and epidemiology all converge. Consensus of ESC/EAS, ACC/AHA.

Five-score assessment

Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)

Scope

Population
general adult population
Intervention
lower LDL-C (diet, drugs, genetics)
Outcome
ASCVD events (MI, stroke, CV death)
Not supported for
  • claim that LDL is the ONLY cause
  • claim that any LDL reduction in any population always reduces events

Evidence sources

Sources

Account mentions

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