evidence card · folic_acid_supplementation_harm
Synthetic folic acid supplementation is harmful; unmetabolized folic acid blocks folate receptors
H2
≈ mixed
stakes critical
1 post scored
·
across 1 account
·
2 sources
Summary
Unmetabolized folic acid (UMFA) is a real biochemical finding at high doses; clinical-outcome harm in humans is not established. Folic acid fortification has a strong, well-established benefit for NTD prevention in pregnancy.
Five-score assessment
Scores not yet assigned for this card. (Legacy card; will be populated on next refinement.)
Scope
Population
general population (excluding pregnant women in whom folic acid supplementation reduces NTD)
Intervention
folic-acid-fortified or -supplemented foods
Outcome
chronic disease
Not supported for
- harm claims for pregnant women (fortification reduces neural tube defects — major benefit)
- blanket avoidance claims